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KMID : 1039520180220020105
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Journal of Audiology & Otology
2018 Volume.22 No. 2 p.105 ~ p.109
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Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients
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Lee Ho-Seok
Kim Woo-Jin
Gong Ji-Sun
Park Kyoung-Ho
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Abstract
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Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing.
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KEYWORD
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Sensorineural hearing loss, Bone marrow derived mesenchymal stem cell, Electrical stimulation
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